MEREDITH IS DEVASTATED TO KNOW THAT DEREK HAS A WIFE, AND CRISTINA IS CONFUSED ABOUT HER STATUS WITH BURKE, ON THE SEASON PREMIERE OF ABC'S "GREY'S ANATOMY," SUNDAY, SEPTEMBER 25

"Raindrops Keep Falling on My Head" - As Meredith and Cristina discuss their relationship woes at the Emerald City Bar, their session of lamenting is interrupted when Joe, the bartender, collapses. And as Chief Webber recovers from brain surgery, he appoints one surgeon as interim chief - much to the dismay of another surgeon -- and he assigns George to report back with hospital gossip. While a devastated Meredith learns more about Derek and Addison's relationship, a confused Cristina tries to make decisions about her connection with Dr. Burke, on the season premiere of "Grey's Anatomy," SUNDAY, SEPTEMBER 25 (10:01-11:00 p.m., ET) on the ABC Television Network.

"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Isaiah Washington as Preston Burke, Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O'Malley, Chandra Wilson as Miranda Bailey and James Pickens, Jr. as Richard Webber.

Guest starring are Kate Walsh as Addison, Steven W. Baily as Joe and Wendy Gazelle as Julie Phillips.

"Raindrops Keep Falling on My Head" was written by Stacy McKee and directed by Peter Horton.

Shonda Rhimes ("Introducing Dorothy Dandridge") is creator and executive producer of "Grey's Anatomy." Mark Gordon ("Saving Private Ryan"), Betsy Beers ("200 Cigarettes") and Jim Parriott ("The American Embassy") are executive producers. Peter Horton is co-executive producer. "Grey's Anatomy" is a Touchstone Television Production.

"Grey's Anatomy" is broadcast in 720 Progressive (720P), ABC's selected HDTV format, with 5.1-channel surround sound.

This program carries a TV-14,D parental guideline.