IZZIE�S ANGER AT THE PHILANDERING ALEX GETS THE BEST OF HER, ON ABC�S �GREY�S ANATOMY�

Rosanna Arquette Guest Stars

�Owner of a Lonely Heart� � Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie�s anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson, on �Grey�s Anatomy,� SUNDAY, JULY 23 (10:00-11:00 p.m., ET) on the ABC Television Network. (Rebroadcast. OAD 12/4/05)

�Grey�s Anatomy� stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Isaiah Washington as Preston Burke, Katherine Heigl as Isobel �Izzie� Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O�Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, and Kate Walsh as Addison Shepherd.

Guest starring are Rosanna Arquette as Constance Ferguson, Timothy Bottoms as Karl Murphy, Margaret Walsh as Dorie Russell, Pat Healy as Tom Russell, Curtis Armstrong as Robert Martin and Sarah Utterback as Nurse Olivia.

�Owner of a Lonely Heart� was written by Mark Wilding and was directed by Dan Minahan.

�Grey�s Anatomy� is broadcast in 720 Progressive (720P), ABC�s selected HDTV format, with 5.1-channel surround sound and Spanish subtitles via secondary closed captioning.

This program carries a TV-14,D parental guideline.