SAM IS GIVEN PILLS AS PART OF A CLINICAL TRIAL IN AN ATTEMPT TO HELP HER REGAIN SOME OF HER LOST MEMORIES -- BUT AS THE MEMORIES COME FLOODING IN, SHE IS REMINDED OF HOW BAD SHE USED TO BE -- ON ABC'S "SAMANTHA WHO?"

"The Pill" � After Dr. Andy (Tony Hale, "Arrested Development") gives Samantha pills as part of a clinical trial to help people with memory loss, she begins to regain multiple memory fragments -- all reminding her of how bad she used to be. But she discovers one pleasant reminder from the past that could have changed her life forever. Meanwhile, when Andrea and Dena are mistaken for a gay couple, Andrea tries to prove that she could hook up with a much hotter woman than Dena, on "Samantha Who?," MONDAY, OCTOBER 27 (9:31-10:01 p.m., ET) on the ABC Television Network.

"Samantha Who?" stars Christina Applegate as Samantha, Jennifer Esposito as Andrea, Kevin Dunn as Howard, Melissa McCarthy as Dena, Tim Russ as Frank, with Barry Watson as Todd and Jean Smart as Regina.

Guest starring are Tony Hale as Dr. Andy Adams, Tate Berney as crying kid, Bryan Keith as valet parker, Rachel Cannon as Carol, Phoebe Dorin and older woman and Brian Phelan as cute guy.

"The Pill" was written by Dawn DeKeyser and directed by Peter Lauer.

"Samantha Who?" is broadcast in 720 Progressive (720P), ABC's selected HDTV format, with 5.1-channel surround sound and Spanish subtitles via secondary closed captioning. This program carries a TV-PG,D,L parental guideline.

This episode of "Samantha Who?" will be available on ABC.com the day after airing on the network for users to watch online.