SAM BEGRUDGINGLY TEAMS UP WITH REGINA TO START A REAL ESTATE BUSINESS -- AND ENDS UP FALLING FOR THEIR FIRST CLIENT -- AND ANDREA TRIES TO SEDUCE TODD'S FRIEND, SETH, IN ORDER TO OBTAIN THE PHONE NUMBER OF A HOT BASKETBALL PLAYER, ON ABC'S "SAMANTHA WHO?"

James Tupper ("Men in Trees") Guest Stars as Sam's First Client, Owen

"The Building" � Desperate for some cash and in need of a job, Samantha reluctantly agrees to team up with Regina and start a real estate business. But while Sam strives to stick to her path of morality, her handsome first client, Owen (James Tupper, "Men in Trees"), could end up throwing her off course. Meanwhile, Andrea tries to seduce Todd's disheveled friend, Seth, in order to obtain the phone number of a professional basketball player, on "Samantha Who?," MONDAY, NOVEMBER 3 (9:31-10:01 p.m., ET) on the ABC Television Network.

"Samantha Who?" stars Christina Applegate as Samantha, Jennifer Esposito as Andrea, Kevin Dunn as Howard, Melissa McCarthy as Dena, Tim Russ as Frank, with Barry Watson as Todd and Jean Smart as Regina.

Guest starring are James Tupper as Owen and Stephen Rannazzisi as Seth.

"The Building" was written by Jim Reynolds and directed by Lee Shallat Chemel.

"Samantha Who?" is broadcast in 720 Progressive (720P), ABC's selected HDTV format, with 5.1-channel surround sound and Spanish subtitles via secondary closed captioning.

A TV parental guideline will be posted closer to airdate.

This episode of "Samantha Who?" will be available on ABC.com the day after airing on the network for users to watch online.