BEFORE THE NEW "GREY'S ANATOMY" SEASON BEGINS, WATCH THE FINALE HAILED BY VIEWERS AND CRITICS IN WHICH A CRISIS UNLIKE ANY BEFORE HITS SEATTLE GRACE

Mandy Moore ("A Walk to Remember") Guest Stars

"Sanctuary" - In the first hour of the two-hour Season 6 finale, a disgruntled man who lost his wife on a Seattle Grace surgical table does the unthinkable and goes on a shooting spree, killing or near-fatally injuring doctors, including Derek Shepherd. In the second hour, "Death and All His Friends," Cristina and a newly-pregnant Meredith must save the lives of one another's significant others when both Derek and Owen are shot by the gunman. Lexie and Mark struggle to save Alex, found shot and dying in the hospital elevator, as Bailey and her patient, Mary, comfort Charles in his last moments. At the same time, Callie and Arizona put aside their personal differences to protect the children's ward and each other. "Grey's Anatomy" airs THURSDAY, SEPTEMBER 16 (9:00-11:00 p.m., ET) on the ABC Television Network.

"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins and Kim Raver as Teddy.

Guest starring Michael O'Neill as Gary, Tom Irwin as Officer Marty, Robert Baker as Charles, Sarah Drew as April, Jesse Williams as Jackson, Nora Zehetner as Reed, Ryan Devlin as Bill, and Mandy Moore as Mary.

"Sanctuary" was written by Shonda Rhimes and directed by Stephen Cragg. "Death And All His Friends" was written by Shonda Rhimes and directed by Rob Corn.

"Grey's Anatomy" is broadcast in 720 Progressive (720P), ABC's selected HDTV format, with 5.1-channel surround sound. This program carries a TV-14,V parental guideline.

For more information on "Grey's Anatomy," visit ABC.com.