DEREK IS VISITED BY HIS ESTRANGED SISTER, AMELIA SHEPHERD, ON ABC'S "GREY'S ANATOMY"

Guest Starring "Private Practice's" Caterina Scorsone as Dr. Amelia Shepherd

James Tupper ("Men in Trees") Guest Stars

"Superfreak" - When Derek receives an unexpected and unwelcome visit from his estranged sister, Amelia, issues between the siblings -- both past and present -- come to the surface; the Chief tries to help Alex when he notices that he's refusing to use the elevators after his near-fatal shooting; and Meredith and Derek continue their efforts to ease Cristina back into surgery after her post-traumatic stress, on "Grey's Anatomy," THURSDAY, OCTOBER 14 (8:00-9:00 p.m., ET) on the ABC Television Network. (Rebroadcast. OAD 10/7/10)

Note: This program replaces the episode of "My Generation" which had been scheduled.

"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Kim Raver as Teddy Altman, Jesse Williams as Jackson Avery and Sarah Drew as April Kepner.

Guest cast includes Caterina Scorsone as Amelia, James Tupper as Andrew Perkins, Dana Davis as Gretchen, Art Chudabala as Jerry, Omar Gooding as Danny, and Jolene Kim as Tess. Co-starring Sean Carrigan as Todd and Arlene Santana as nurse.

"Superfreak" was written by Mark Wilding and directed by Michael Pressman.

"Grey's Anatomy" is broadcasted in 720 Progressive (720P), ABC's selected HTV format, with 5.1-channel surround sound. This program carries a TV-14,D parental guideline.

For more information on "Grey's Anatomy" please visit ABC.com.